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Extracellular signal-regulated kinase 1/2 (ERK1/2) kinase phosphorylation has been demonstrated in N2a cells that overexpress SVCT2 and undergo morphological changes with the presence of numerous filopodia and processes (Thomas and Huganir, 2004)

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doi: 10.5935/0004-2749.20140050

These findings have significant implications for the development and monitoring of NAD-targeted therapies, emphasizing the need for personalized approaches in metabolic interventions